Open calls

Open call for applications for enrolment and scholarships for the Research Year.

The Graduate School of Health is now accepting applications for enrolment and scholarships for the Research Year.

You can apply for enrolment as well as scholarships from Aarhus Universitets ForskningsFond in one application. 

  • Application deadline: 15 October 2016, midnight
  • Earliest possible starting date: 1 February 2017
  • Reply: ultimo December 2016

Please be aware that documents and mandatory attachment for assessment has been updated in September 2016. Please make sure to use the new documents in the application.

You can read about the updated criteria and the application process in general by clicking here.

Access the application form by clicking on "Research Year Call April 2016" at the bottom of this page.

 

 

PhD fellowship at Department of Nuclear Medicine & PET Centre – Noradrenergic dysfunction and slowing of cortical oscillatory activity in Parkinson´s disease patients with mild cognitive impairment

The Department of Nuclear Medicine and PET Center at the Department of Clinical Medicine, HEALTH, Aarhus University is offering a PhD fellowship commencing on 1st February 2017 or as soon as possible hereafter.

The application deadline is 15th October 2016.

We are seeking a PhD candidate within medical engineering qualifications and ideally some previous research experience within the field of neuroimaging of neurodegenerative disorders.

The candidate should be interested in developing a career in the field of Neuroimaging.

Good interpersonal and communication skills, ability to work in a team, and fluency in Danish and English are required.

The department is part of the Head-Heart Centre at Aarhus University Hospital and has a long tradition for international research especially in the fields of neuroscience, cardiology, oncology and hepatology. The translational aspect is highly prioritised, including development of preclinical models of diseases. The research in the Neuroscience Programme of the PET Centre is headed by Professor David Brooks and focuses on developing and using imaging biomarkers to understand the mechanisms of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. The department has an 11C and 18F developmental radiochemistry facility for making novel PET radiotracers for brain imaging with 12 GMP hot cells and a 20-year history of successful experimental tracer production. The PET Centre is located at the Danish Neuroscience Centre (DNC) which also houses Functional Neuroimaging, Neurology, Neurosurgery, and Psychology researchers, Neuropathology and Stereology, and an MEG suite as well as animal PET / MRI and animal holding facilities.

The future PhD fellow will participate actively in this network and collaborate with a range of professionals, including basic scientists, physicists and radiochemists, clinical investigators, lab technicians, etc.

Project description

Patients with Parkinson´s disease (PD) develop both motor and non-motor deficits. Mild cognitive impairment (MCI) and dementia are highly prevalent causes of severe disability in PD patients and are related to early neurophysiological and neurochemical abnormalities.

Thus, slowing of the cortical oscillations occur early in the PD patients that are in risk of cognitive deterioration or dementia. Subcortical structures, including thalamus, are important for the modulation and generation of cortical oscillatory activity, and dysfunction of their rhythm generating ability may be related to the severity of cognitive impairment in patients with neurodegenerative disorders. Another characteristic of early stage Parkinson´s disease is the loss of noradrenergic input to thalamus. This loss of noradrenergic innervation may alter its rhythm-generating ability and reduces oscillations in the alpha and beta frequency range, while increasing oscillations in the slower theta and delta frequency range. However, the role of noradrenaline deficits in slowing of cortical oscillations has not been examined directly in humans.

Here, we undertake a longitudinal multimodal imaging study to elucidate the combined roles of noradrenergic deficits and neurophysiological abnormalities in MCI and dementia in PD patients. Specifically, noradrenergic deficits, as measured with positron emission tomography (PET), using the selective tracer [11C]MeNER, will be correlated with neurophysiological abnormalities detected with electroencephalography, magnetoencephalography and with longitudinal measurements of cognitive  function.

The project is funded by the Danish Council for Independent Research.

Principal supervisor

Professor David Brooks
E-mail: dbrooks@clin.au.dk
HEALTH, Aarhus University

Qualifications 

  • A first degree or higher in medical engineering or academic qualifications on similar level/area.
  • Interested in neuroscience with preferably some research experience within neuroimaging.
  • Good communication and interpersonal skills.
  • Fluency in Danish and English required
  • Professional qualifications relevant to the PhD programme.
  • Relevant work experience and other professional activities.
  • Familiarity with statistics.

General job description

Your key tasks as a PhD fellow at the Department of Nuclear Medicine and PET center are to: 

  • Manage and carry through your research project.
  • Take PhD courses.
  • Teach and disseminate your research.
  • Write scientific articles and your PhD thesis.

The PhD project will be take place at the Department of Nuclear Medicine and PET center, Nørrebrogade 44, 8000 Aarhus C. The unit is planned to move to the new University hospital (DNU) in Skejby in 2019.

Formal requirements

The position is available for a 3-year period for applicants holding a relevant  degree. The chosen candidate will have to apply for enrolment in one of the four annual application rounds at the Graduate School of Health, Aarhus University. It is a requirement that both the candidate and the project are accepted for enrolment to be able to start the PhD fellowship.

Terms of employment

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations.

The position is covered by the Job Structure for Academic Staff at Universities (2007). Questions For further information, please contact Professor David Brooks tel. 78461071 or MD, PhD Adjmal Nahimi on anah@clin.au.dk or at 78464379.

Application procedure

Please send your motivated application by email to Research Coordinator Anne Sofie M. Andersen asma@clin.au.dk and include your CV, diploma and transcript of records, and at least one recommendation.

Applications have to be received no later than 15th October 2016.

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Revised 28.09.2016